This program focuses on harms from opioid-type medications, the development and fundamental features of opioid use disorder, and how physicians can play a key role in reversing what has been called the “opioid epidemic” through evidence-based treatment of opioid use disorder. Sarah E. Wakeman, MD, Medical Director, Massachusetts General Substance Use Disorder Initiative, will help learners understand the basis of opioid use disorder and the key attributes of successful treatment, and will provide examples of how interventions can be applied at various points of patient engagement, and within different clinical practice settings.